Analysis Note

Single spot by TLC

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetthermolysin

Product does not compete with ATP.

Target IC₅₀: 4.6 µM against the conversion of big endothelin-1 to endothelin

General description

Effective concentration: 1-10 µM.

Inhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC₅₀ = 4.6 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.Howell, S., et al. 1993. Biochem. J. 290, 159.

Packaging

5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)